S3062
Sigma
Anti-α-Synuclein antibody produced in rabbit
IgG fraction of antiserum, buffered aqueous solution
| Synonym: | Anti-SNCA |
| MDL number: | MFCD02095740 |
Description
| Immunogen | synthetic peptide corresponding to a sequence near the C-terminus of human α-synuclein (amino acids 111-132 with C-terminally added lysine) conjugated to KLH. This sequence is highly conserved (90% homology) in mouse and rat α-synuclein. This sequence has no homology with β- and γ-synuclein. |
| Physical form | Solution in 0.01 M phosphate buffered saline, pH 7.4, containing 15 mM sodium azide. |
Properties
| antibody form | IgG fraction of antiserum |
| clone | (polyclonal) |
| form | buffered aqueous solution |
| mol wt | antigen mol wt 19 kDa |
| species reactivity | rat, human |
| application(s) | immunoblotting: 1:1,000 using extract of rat brain homogenate |
| immunohistochemistry (formalin-fixed, paraffin-embedded sections): 1:200 using formic acid treated sections of Alzheimer′s Disease brain | |
| microarray: suitable | |
| Gene Information | human ... SNCA(6622) |
| rat ... Snca(29219) | |
| storage temp. | −20°C |
Safety
| WGK Germany | NWG |
Related Products
References
| reference | Fujita, S., et al., Phosphorylated α-synuclein in normal mouse brain. FEBS Lett. 572, 227-232, (2004) Abstract |
| Amadoro, G., et al., Spontaneous aggregation and altered intracellular distribution of endogenous α-synuclein during neuronal apoptosis. J. Alzheimers Dis. 13, 151-160, (2008) Abstract |
